| Genetic Condition | Main Cancers | Gene | Location | Year |
| Hereditary retinoblastoma | Retinoblastoma | RB1 | 13q14 | 1986 |
| Sarcomas | ||||
| Hereditary Wilms' tumor | Wilms' tumor | WT1 | 11p13 | 1990 |
| Li-Fraumeni syndrome | Breast Cancer | TP53 | 17p13 | 1990 |
| Sarcomas | ||||
| Brain tumor | ||||
| Neurofibromatosis 1 | Sarcomas | NF1 | 17q11 | 1990 |
| Brain tumor | ||||
| Familial adenomatous | Colon Cancer | APC | 5q21 | 1991 |
| polyposis | ||||
| Neurofibromatosis 2 | Acoustic neuroma | NF2 | 22q12 | 1993 |
| Brain tumor | ||||
| von Hippel-Lindau | Renal Cancer | VHL | 3p25 | 1993 |
| syndrome | Pheochromocytoma | |||
| Brain tumor | ||||
| Multiple endocrine | Pheochromocytoma | RET | 10q11 | 1993 |
| neoplasia 2 | Medullary thyroid cancer | |||
| Tuberous sclerosis 2 | Renal Cancer | TSC2 | 16p13 | 1993 |
| Brain tumor | ||||
| Hereditary non-polyposis | Colon Cancer | hMSH2 | 2p16 | 1993 |
| Colon Cancer 1 | Endometrial Cancer | |||
| Stomach Cancer | ||||
| Hereditary non-polyposis | Colon Cancer | hMLH1 | 3p21 | 1994 |
| Colon Cancer 2 | Endometrial Cancer | |||
| Stomach Cancer | ||||
| Hereditary non-polyposis | Colon Cancer | hPMS1 | 2q32 | 1994 |
| Colon Cancer 3 | Endometrial Cancer | |||
| Stomach Cancer | ||||
| Hereditary non-polyposis | Colon Cancer | hPMS2 | 7p22 | 1994 |
| Colon Cancer 4 | Endometrial Cancer | |||
| Stomach Cancer | ||||
| Hereditary Melanoma 1 | Melanoma | CDKN2 | 9p21 | 1994 |
| Hereditary Breast Cancer 1 | Breast Cancer | BRCA1 | 17q21 | 1994 |
| Ovarian Cancer | ||||
| Ataxia telangiectasia | Breast Cancer | ATM | 11q22-23 | 1995 |
| Lymphoma | ||||
| Hereditary Breast Cancer 2 | Breast Cancer | BRCA2 | 13q12-13 | 1995 |
| Hereditary Melanoma 2 | Melanoma | CDK4 | 12q13 | 1996 |